这句英语怎么分析??

Source:

She hesitated as she made herself ask, "Is he giving you any trouble of any kind? I mean, what with his having to change desk partners so much?"

--The Birthday Present, Chicken Soup for The Unsinkable Soul

 

这句话，what with his having to change desk partners so much?

意思我大致可以猜到 但我想了解一下它的结构?

如果觉得上下文不够请留言

what （is wrong）with his having to change desk partners so much?what is wrong with sthsth=one's dong sth(名词性结构,术语忘记了)one's dong sth:his having to change desk partners so much